Uremic myopathy

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Uremic myopathy: is oxidative stress implicated in muscle dysfunction in uremia?

Renal failure is accompanied by progressive muscle weakness and premature fatigue, in part linked to hypokinesis and in part to uremic toxicity. These changes are associated with various detrimental biochemical and morphological alterations. All of these pathological parameters are collectively termed uremic myopathy. Various interventions while helpful can't fully remedy the pathological pheno...

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Uremic osteoporosis

Abnormalities in bone turnover, mineralization, and volume represent one of the three components of chronic kidney disease-related mineral and bone disorder (CKD-MBD). The risk of hip fracture is considerably high, while the risk of spinal compression fracture may not be more elevated among CKD patients than in general population. The relationship between bone fracture and bone mineral density ...

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Uremic Toxins

The genomic action of calcitriol (1,25-dihydroxy-vitamin D3) is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs). Although renal failure is associated with resistance to the action of calcitriol, the mechanism of this resistance is not well understood. Therefore, we used the electrophoretic mobility shift assay to compare the ability of ...

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Uremic Encephalopathy

Patients with renal failure often have signs and symptoms related to fluid and electrolyte disturbances, anemia, malnutrition, bone disease and gastrointestinal problems. One of those complications is the uremic encephalopathy. With the introduction of dialysis and renal transplantation, the incidence and severity of uremic encephalopathy have declined, but many patients fail to fully respond t...

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Uremic frost

Full blown uremic syndrome of chronic kidney disease (CKD) is seldom seen these days due to early initiation of renal replacement therapies (RRT) [1, 2]. Uremic frost is a manifestation of advanced CKD but rarely seen due to effective RRT. We came across a 21-year-old male patient, brought to us with complaints of nausea, anorexia, oliguria and recent onset alteration in sensorium. On physical ...

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ژورنال

عنوان ژورنال: Kidney International

سال: 2002

ISSN: 0085-2538

DOI: 10.1046/j.1523-1755.2002.00614.x